Atopic dermatitis (AD) is a chronic, inflammatory skin disease characterized by severe pruritus or itchiness, and dryness of the skin. Because its development involves a complex interaction of genetic, environmental, and immunological factors, prescribing an effective treatment is difficult. Earlier studies have demonstrated that fig (Ficus carica, Moraceae) leaves and fruits are rich in polyphenols and may possess antioxidant, anti-inflammatory, antiviral, and antibacterial properties. These properties, particularly reducing inflammation, are often useful in treating AD. Therefore, these authors conducted a randomized, double-blind, placebo-controlled, clinical trial to investigate the effects of an aqueous extract of dried fig fruit on the severity of AD.

To prepare the treatment cream used in this study, samples (100 g) of edible fig fruit, purchased from local markets of Estahban County in Fars Province, Iran, in September 2014. The fruits were washed and macerated in 200 mL of water at 77° F (25° C) for…