A migraine headache is among the most disabling inflictions globally, in part, because it adversely affects quality-of-life. Some pharmaceuticals are used prophylactically to decrease migraine frequency and severity, but they have unwanted side effects. In traditional Iranian medicine, coriander (Coriandrum sativum, Apiaceae) fruit, rose (Rosa damascena, Rosaceae) flower, and violet (Viola odorata, Violaceae) flower are used to treat headache. According to the authors, there are no published studies evaluating the combination of coriander, rose, and violet (CRV) as a treatment of pain or migraine. Hence, the purpose of this randomized, double-blind, placebo-controlled study was to evaluate the effect of CRV on the frequency, duration, and severity of migraine.

Patients (n = 88, aged 15-45 years) with a diagnosis of migraine headache (with or without aura) according to the International Headache Society (IHS) criteria and who visited Besat Neurology Clinic No.4 at Kerman University of…