Cardiovascular (CV) diseases are the leading cause of world mortality, with 7.4 million of their 17.7 million annual deaths due to coronary artery disease (CAD). CAD risk factors include diabetes mellitus (diabetes type 2 [DT2]), hypertension, dyslipidemia, obesity, poor diet, tobacco (Nicotiana tabacum, Solanaceae) smoking, lack of exercise, and alcohol abuse. Acute myocardial infarction and death—two primary effects associated with CAD—account for more than 90% of all CAD-related outcomes. Atherosclerotic plaques form when vascular endothelial cells express chemotactic and adhesion molecules, starting the inflammatory process crucial to CAD’s pathogenesis. Within a healthy diet, cardioprotective foods can modulate expression of proinflammatory cytokines and inflammation markers and help control risk factors like DT2, hypertension, dyslipidemia, and obesity. Phenolic compounds and unsaturated fats found in olive (Olea europaea, Oleaceae) oil (OO) show benefits in this area and may improve CV outcomes overall. Virgin OO (VOO) is produced by…