Irritable bowel syndrome (IBS) is characterized by abdominal pain and alterations in bowel movements. Patients with IBS have a higher rate of depression and anxiety and have a decreased quality of life (QOL). Boswellia (Boswellia carteri, Burseraceae) gum resin has anti-inflammatory properties and antidepressant effects. Ginger (Zingiber officinale, Zingiberaceae) rhizome has antibacterial, antifungal, and antioxidant effects. Yarrow (Achillea millefolium, Asteraceae) aerial part has anxiolytic effects and is used to treat gastritis. Boswellia and ginger have been used to treat IBS. The purpose of this randomized, placebo-controlled study was to evaluate the effects of a combination of Boswellia, ginger, and yarrow on IBS symptoms, QOL, anxiety, and depression in patients with IBS.

Patients (n = 60, aged > 18 years) with mild-to-moderate IBS according to ROME III criteria were recruited from the psychosomatic clinic at Isfahan University of Medical Sciences (IUMS), Isfahan, Iran from 2015 to 2016. Excluded patients…