Lāʻau Lāpaʻau || Clinical Pharmacokinetics of Green Coffee Bean Extract

Crooked Bear Creek Organic Herbs

Coffee (Coffea arabica, Rubiaceae) beans are used in many cultures across the globe to brew the popular caffeinated beverage. Caffeine and coffee have been linked with reduced incidence of metabolic syndrome and diabetes, lower serum triglycerides, better athletic performance, and improved memory and attention. Other than caffeine, antioxidant compounds such as chlorogenic acids (CGA) may underlie coffee’s benefits, as some studies report similar results for decaffeinated coffee. Among coffee CGAs, 5-CQA comprises about 35% of CGAs in roasted coffee and 56-62% in green coffee beans. One serving of coffee provides 20-675 mg CGAs, depending on the type of roast, preparation, serving size, and many other factors.

CGAs, like most polyphenolic compounds, are not well absorbed in the human body but are broken down or metabolized to smaller units in the gut. Coffee CGAs are differentially absorbed and/or metabolized in humans, with large individual variation. It has been suggested…

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