Osteoarthritis (OA) is a common age-related disorder associated with chronic inflammation, joint pain, decreased mobility, and negative impact on quality of life. OA of the knee is the most common form of arthritis. Acetaminophen and nonsteroidal anti-inflammatory drugs (NSAIDs) are the primary medications used for symptoms related to OA of the knee. These pharmacological interventions often lead to gastrointestinal, renal, and cardiovascular risk. Gum resin extracted from boswellia (Boswellia serrata, Burseraceae) has been used in Ayurvedic medicine to treat chronic inflammatory diseases, including OA. Studies have shown boswellia extract to be beneficial for treating age-related inflammatory disorders. In this randomized, double-blind, placebo-controlled pilot study, Boswellin (Sabinsa Corporation; East Windsor, New Jersey) was evaluated for its efficacy and safety in treating OA of the knee and to determine the interactions of b-boswellic acid with progression of OA of the knee.

Male and female patients between the ages of 35 and…