Lāʻau Lāpāʻau || Clinical Safety of Ephedrine Alkaloid-free Ephedra Herb Extract (EFE)

Crooked Bear Creek Organic Herbs

Ephedra (Ephedra sinicaE. equisetina, and E. intermedia; Ephedraceae) herb (primarily stem tissue) is used in Japanese Traditional Medicine (Kampo) formulations. Ephedra herb is defined in the Japanese Pharmacopoeia as stem material containing ˃0.7% ephedrine alkaloids (ephedrine and pseudoephedrine). Ephedrine alkaloids (EAs) are thought to be responsible for the analgesic, anti-inflammatory, antipyretic, antitussive, and diaphoretic effects of ephedra. EAs stimulate adrenaline receptors and may induce adverse effects such as hypertension, heart palpitations, insomnia, and dysuria (painful urination). Due to deaths attributed to excessive intake or misappropriate use of ephedra, the US Food and Drug Administration (FDA) has prohibited the sale of supplements containing EAs. These authors have reported that ephedrine alkaloid-free ephedra extract (EFE) has analgesic, anti-influenza, and c-Met receptor inhibitory effects (the latter suppresses the metastasis of cancer cells). These findings suggest that the pharmacological effects of ephedra are not solely due to EAs, and…

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