Lāʻau Lāpaʻau || Ashwagandha Beneficial for Symptom Exacerbation in Schizophrenia

Crooked Bear Creek Organic Herbs

Immune-inflammatory dysregulation has been linked with the exacerbation of symptoms in patients with schizophrenia. There is some evidence that adjunctive treatment with non-steroidal anti-inflammatory drugs (NSAIDS) may be beneficial; however, NSAIDs may cause adverse effects (AEs). Ashwagandha (Withania somnifera, Solanaceae) root extract has demonstrated immunomodulatory and anti-inflammatory activity. The purpose of this randomized, double-blind, placebo-controlled study was to evaluate the effect of ashwagandha on recently exacerbated symptoms in patients with schizophrenia.

Outpatients (n=66, aged 18-75 years) with schizophrenia or schizoaffective disorder according to the Diagnostic and Statistical Manual of Mental Disorders, Fourth Edition Text Revision (DSM-IV-TR) and Mini-International Neuropsychiatric Interview participated in this study conducted from April 2013 to July 2016 at the ambulatory clinics associated with the Comprehensive Recovery Services of Western Psychiatric Institute Clinic, University of Pittsburgh Medical Center, Pittsburgh, Pennsylvania. Other inclusion criteria were a Positive and Negative Syndrome Scale (PANSS) total score ≥ 60…

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